Minicurso – As aulas ser\u00e3o ministradas em portugu\u00eas<\/b><\/p>\n
Inova\u00e7\u00e3o em f\u00e1rmacos no ambiente acad\u00eamico com foco na otimiza\u00e7\u00e3o molecular<\/b><\/p>\n
Resumo: <\/i>A capacidade transformadora da inova\u00e7\u00e3o em gerar novos produtos e processos \u00e9 a forca motriz do desenvolvimento e est\u00edmulo \u00e0 pesquisa. No ambiente acad\u00eamico a inova\u00e7\u00e3o, por meio de parcerias com ambiente corporativo, tem gerado novas tecnologias com potencial para alcan\u00e7ar o mercado. Frente aos desafios impostos ao desenvolvimento de novos f\u00e1rmacos, a utiliza\u00e7\u00e3o de estrat\u00e9gias da Qu\u00edmica Farmac\u00eautica Medicinal como a otimiza\u00e7\u00e3o molecular tem importante contribui\u00e7\u00e3o na redu\u00e7\u00e3o das falhas e atritos encontrados durante o processo. Neste curso ser\u00e3o abordadas as ferramentas utilizadas para melhorias nas propriedades f\u00edsico-qu\u00edmicas, farmacocin\u00e9ticas e farmacodin\u00e2micas de compostos com aplica\u00e7\u00e3o na \u00e1rea farmac\u00eautica. Sob a perspectiva acad\u00eamica ser\u00e3o apresentados os exemplos da utiliza\u00e7\u00e3o dessas estrat\u00e9gias que permitiram o desenvolvimento de novos f\u00e1rmacos.<\/p>\n
Short-Course \u2013 The lectures will be in Portuguese<\/b><\/p>\n
Innovation in the academic environment with a focus on molecular optimization<\/b><\/p>\n
Abstract: <\/i>The capacity of innovation to transform reality and generate new products and processes is the driving force behind the development and research in the pharmaceutical field. In the academic environment, the innovation explores partnerships with the corporate environment, and the establishment of such association has been able to generate new technologies with the potential to achieve the market. Faced with the challenges imposed on the development of new drugs, the use of Medicinal Chemistry approaches such as molecular optimization has an essential contribution to reducing the failures and friction encountered during the drug development process. In this short course, the tools used to improve the physicochemical, pharmacokinetic, and pharmacodynamic properties of small molecules with application in the pharmaceutical area will be discussed. From the academic perspective, examples of the use of these strategies that allowed the development of new drugs will be presented.<\/p>\n Minicurso – As aulas ser\u00e3o ministradas em portugu\u00eas Inova\u00e7\u00e3o em f\u00e1rmacos no ambiente acad\u00eamico com foco na otimiza\u00e7\u00e3o molecular Resumo: A capacidade transformadora da inova\u00e7\u00e3o em gerar novos produtos e processos \u00e9 a forca motriz do desenvolvimento e est\u00edmulo \u00e0 pesquisa. No ambiente acad\u00eamico a inova\u00e7\u00e3o, por meio de parcerias com ambiente corporativo, tem gerado…<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"post_series":[],"class_list":["post-527","post","type-post","status-publish","format-standard","hentry","category-sem-categoria","entry","no-media"],"_links":{"self":[{"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/posts\/527","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/comments?post=527"}],"version-history":[{"count":11,"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/posts\/527\/revisions"}],"predecessor-version":[{"id":777,"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/posts\/527\/revisions\/777"}],"wp:attachment":[{"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/media?parent=527"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/categories?post=527"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/tags?post=527"},{"taxonomy":"post_series","embeddable":true,"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/post_series?post=527"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nSickle Cell Disease (SCD) is one of the most common hematological and genetic disease caused by a single mutation in the ?-globin gene, which leads to production of the abnormal hemoglobin S (HbS).\u00a0 <\/span>The SCD pathophysiology is complex and multifactorial. At low oxygen tension, erythrocytes containing HbS polymerize and acquire a sickle shape, with exhbits abnormal adhesion to endothelium, culminting to the vaso-occlusion process. In addition, inflammatory process contributes to develop several acute and chronic clinical manifestations. Currently, the few therapeutic options are one of the cruelest faces of this disease. Among the interventional approaches, the increase in fetal hemoglobin levels (HbF) revealed to be a validate strategy. In this lecture, the Medicinal Chemistry of HbF inducers and advances reached by our research group will be discussed in the last years.<\/p>\n","protected":false},"excerpt":{"rendered":"