{"id":662,"date":"2022-07-26T19:17:01","date_gmt":"2022-07-26T22:17:01","guid":{"rendered":"https:\/\/brazmedchem.org\/2022\/?p=662"},"modified":"2022-07-26T19:17:07","modified_gmt":"2022-07-26T22:17:07","slug":"paulo-r-r-costa-ph-d","status":"publish","type":"post","link":"https:\/\/brazmedchem.org\/2022\/paulo-r-r-costa-ph-d\/","title":{"rendered":"Paulo R. R. Costa, Ph.D."},"content":{"rendered":"<p style=\"text-align: justify;\">Title:<b> Modified Isoflavonoids: Design, Synthesis and Antiproliferative Activity<span class=\"Apple-converted-space\">\u00a0<\/span><\/b><\/p>\n<p style=\"text-align: justify;\"><b>Abstract:<\/b> An antiproliferative natural pterocarpan was the starting point to design synthetic pterocarpanquinones. After a SAR study of these compounds in a panel of cancer cells, including some with MDR phenotype, <b>LQB-118<\/b> was selected for <i>in vivo<\/i> experiments and presented anti-cancer (leukemia, prostate) and antileishmanial properties in mice. Additional SAR studies led to <b>LQB-223<\/b>, a 5-carba-11-aza-pterocarpan. This compound and some structural analogues presented potent antiproliferative effect in leukemia and mama cancer cell lines. New pterocarpans, 5-Carba-pterocarpans and 1-carba-isoflavanones were also synthesized and showed promising antiproliferative activity. The synthesis of these compounds and possible mechanisms of action will be discussed.<\/p>\n<p style=\"text-align: justify;\"><span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Title: Modified Isoflavonoids: Design, Synthesis and Antiproliferative Activity\u00a0 Abstract: An antiproliferative natural pterocarpan was the starting point to design synthetic pterocarpanquinones. After a SAR study of these compounds in a panel of cancer cells, including some with MDR phenotype, LQB-118 was selected for in vivo experiments and presented anti-cancer (leukemia, prostate) and antileishmanial properties in&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"post_series":[],"class_list":["post-662","post","type-post","status-publish","format-standard","hentry","category-sem-categoria","entry","no-media"],"_links":{"self":[{"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/posts\/662","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/comments?post=662"}],"version-history":[{"count":1,"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/posts\/662\/revisions"}],"predecessor-version":[{"id":667,"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/posts\/662\/revisions\/667"}],"wp:attachment":[{"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/media?parent=662"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/categories?post=662"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/tags?post=662"},{"taxonomy":"post_series","embeddable":true,"href":"https:\/\/brazmedchem.org\/2022\/wp-json\/wp\/v2\/post_series?post=662"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}