Prof. Dr. Stefan Wölfl

Professional Appointments

2003 – present. University-Professor and Head of Department for Pharmaceutical Bioanalytics
Institute of Pharmacy and Molecular Biotechnology
Heidelberg University, Heidelberg, Germany

2000-2003 Head of independent Research Group „Molecular Biology“ and Faculty
Member (Privatdozent)
University Hospital, Friedrich-Schiller-Universität Jena, Jena, Germany

1994-2000 Junior Group Leader and Habilitation, Hans-Knöll-Institut for Natural Product
Research, Jena, Germany and Friedrich-Schiller-Universität Jena, Jena, Germany
Habilitation and “venia legendi” awarded in 1999 in Molecular Biology
Faculty of Biosciences of Friedrich-Schiller-Universität Jena, Jena, Germany
Education and Training

1990-1994 Post Doctoral Researcher, Massachusetts Institute of Technology (MIT),
Cambridge, USA (Advisor: Alexander Rich)

1986-1990 Graduate Student/PhD Studies at the Freie Universität Berlin, Berlin, Germany
(Advisor: Burghardt Wittig)
PhD Thesis: “Direct Genomic Sequencing” of the chicken lysozyme-gene:
no correlation between DNA-methylation and gene expression
PhD in Biochemistry awarded by Faculty of Chemistry, Freie Universität Berlin

1981-1984/85. Student of Pharmacy, Freie Universität Berlin
Staatsexamen Pharmazie (Government Examination) in Berlin and Munich
Approbation as certified Pharmacist (1984/1985)
Professional experience in Public Pharmacy and Pharmaceutical Industry
Other professional activities

1998-2006 Co-founder of Biotechnology and Diagnostics Start-up and
Clondiag Chip Technologies GmbH, Jena, Germany
2007-2016 Advisory Board Member of Biomol GmbH, Hamburg, Germany

Awards
1998/1999 Special Vote for applied Science of the 1998 Thuringia Research-Award
(Thüringer-Forschungspreis): “Micro Offset Printing – eine universelle BiochipTechnologie”

Scientific Society Memberships
Member of the European Academy of Science and Arts, Salzburg (Class IV)
Member of Sigma Xi Scientific Research Society (MIT chapter)

Selected recent Publications
1 Varga K, Sikur N, Paszternák A, Friesenhahn AL, Zymela FE, Bagaméry F, Tábi T, Wölfl S. (2025)
Resveratrol restores insulin signaling and balances mitochondrial biogenesis and autophagy in streptozotocininduced neurodegeneration in vitro. Eur J Pharm Sci. 212:107202. PMID: 40653095

2 Zhang JJ, Xu QJ, Schmidt C, Maaty MAAE, Song J, Yu C, Zhou J, Han K, Sun H, Casini A, Ott I, Wölfl S.
(2023) Elucidating the Multimodal Anticancer Mechanism of an Organometallic Terpyridine Platinum(II) NHeterocyclic Carbene Complex against Triple-Negative Breast Cancer In Vitro and In Vivo.

J Med Chem.
66(6):3995-4008. PMID: 36898000

3 Zuieva A, Can S, Boelke F, Reuter S, Schattschneider S, Töpfer E, Westphal A, Mrowka R, Wölfl S. (2022)
Real-time monitoring of immediate drug response and adaptation upon repeated treatment in a microfluidic
chip system. Arch Toxicol. 2022 May;96(5):1483-1487. PMID: 35304627