13:00 – 15:00pm – 20th
sHORT-COURSES
15:00 – 15:30pm – 20th
CoffeE-break
15:30 – 17:00pm – 20th
sHORT-COURSES
08:00 – 10:00am – 21st
sHORT-COURSES
10:00 – 10:30am – 21st
CoffeE-break
10:30 – 12:00am – 21st
sHORT-COURSES
12:00 – 13:00pm – 21st
Lunch
14:00 – 18:00pm – 21st
REgistration
09:00 – 12:00am – 21st
Young Medicinal Chemistry
12:00 – 13:00pm – 21st
Lunch
13:00 – 15:00pm – 21st
Young Medicinal Chemistry
Chair: Marilia Valli
15:00 – 15:30pm – 21st
CoffeE-break
15:30 – 17:00am – 21st
Young Medicinal Chemistry
Chair: Marilia Valli
19:00 – 19:30pm – 21st
Opening Ceremony
Chairs: Dr. Floriano Paes & Dr. Lídia Lima
19:30-20:30pm – 21st
Opening LecturE
Chair: Dr. Rafael Guido
Replenishing the malaria drug discovery pipeline: Advances in Hit Generation for Antimalarial
Drug Discovery
James Duffy
Medicines for Malaria Venture
20:30-22:30pm – 21st
Welcome reception
9:00 – 10:20am – 22nd
Tematic Session I:
AI in Drug discovery
Chairs: Carlos Mauricio R. Sant’Anna & Gustavo Trossini
9 – 9:40 am – SPEAKER 1
Synergizing Computational Chemistry and AI for Early-Stage Drug Discovery
Dr. Francesco Gentile
Ottawa Institute of Systems Biology, University of Ottawa
9:40 – 10:20 am – SPEAKER 2
Reaction-driven generation of bioactive compounds from ultra-large chemical spaces
Dr. Didier Rognan
University of Strasbourg
10:20 – 10:50am – 22nd
CoffeE-break
10:50 – 12:30am – 22nd
Tematic Session I:
AI in Drug discovery
Chairs: Carlos Mauricio R. Sant’Anna & Gustavo Trossini
10:50 – 11:20 am – SPEAKER 3
Assault, Siege, Trojan Horses or Gentle Disarmament: Four Molecular Strategies to Fight Bacterial Infections
Mark Brönstrup
Chemische Biologie (CBIO)
HZI – Helmholtz-Zentrum für Infektionsforschung GmbH
11:20 – 11:50 am – SPEAKER 4
Explainable Artificial Intelligence for the Design of Novel Anticancer RNA- and Peptide-Based Therapeutics
Dr. André Silva Pimentel
PUC-Rio
11:50 – 12:20 am – SPEAKER 5
Using Generative AI for Many-Objective Small-Molecule Design
Dr. Laurent Dardenne
LNCC
9:00 – 10:20am – 22nd
Tematic Session II:
Early Drug Discovery
Chairs: Luzineide Tinoco & Daniela Trivella
9 – 9:40 am – SPEAKER 6
Approaches for Natural Product Drug Discovery from compound libraries to Hit Identification
Prof. Emeritus Ronald J. Quinn
AM, FTSE – Griffith University
9:40 – 10:20 am – SPEAKER 7
Putting your compounds to good use: EU-OPENSCREEN’s open compound sharing initiative
Dr. Bahne Stechmann
Deputy Director
EU-OPENSCREEN ERIC
10:20 – 10:50am – 22nd
CoffeE-break
10:50 – 12:30am – 22nd
Tematic Session II:
Early Drug Discovery
Chairs: Luzineide Tinoco & Daniela Trivella
10:50 – 11:20 am – SPEAKER 8
Connecting Biology to Chemistry through High Throughput Screening
Dr Yuhong Du
Emory University, Atlanta, GA, USA
11:20 – 11:50 am – SPEAKER 9
Discovery and Optimization of Small-Molecule Tools Targeting Necroptosis Cell Death
Dr. Rui Moreira
Universidade de Lisboa
11:50 – 12:20 am – SPEAKER 10
The direct approach: the role of chemical proteomics in drug target deconvolution
Prof. Susan Wyllie
Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee
12:30 – 13pm – Sponsor’s Lecture 1
Clarivate’s Cortellis Drug Discovery Intelligence
12:30 -14:00pm – 22nd
Lunch
14:00 – 15:15pm – 22nd
Lecture 1
Special Session in tribute to prof. Carlos alberto manssour Fraga
Chair: Prof. Luiz Carlos Dias
Targeting new E3 Ligases and validating them for PROTAC development
Dr. Stefan Knapp
Johann Wolfgang Goethe-University
15:15 – 16:15pm – 22nd
Lecture 2
Chair: Dr. Stefan Laufer
Development and Characterization of Kinase sparing Aurora Kinase A Ligands for improved Cancer Therapy
Dr. Lars Zender
Universität Tubingen
16:15 – 17:45pm – 22nd
Coffee + Poster Session I
18:00 – 19:30pm – 22nd
SBQ MedChem Division Meeting
ATENTION: Meeting in Geribá room
09:00 – 11:00am – 23rd
Round Table “New Challenges in the Brazilian Pharma Industry”
Mediator: Dr. Glaucius Oliva (USP)
2 blocks: 1st block 15min presentation for each debater, 2nd block: 1h mediator + audience questions
Sustainable Development, Science, Technology, and Innovation, and the Economic-Industrial Health Complex
Carlos A. Grabois Gadelha
Desenvolvimento Sustentável, CT&I e Complexo Econômico-Industrial da Saúde (CEE/ENSP–Fiocruz/MS).
Exploring R&D Synergies in Natural Products, Small Molecules and Enabling Drug Technologies
Hátylas Azevedo
Aché Laboratórios
Sustainable and Responsible Radical Innovation in Health: the CNPEM experience
Dra. Maria Augusta Arruda
Brazilian National Centre for Research in Energy and Materials (LNBIO-CNPEM)
Drug Discovery at Eurofarma Laboratórios
Luis Eduardo Reina Gamba
Head of Medicinal Chemistry – Drug Discovery, Eurofarma.
11:00 – 12:00pm – Technical Lecture
CAS BioFinder: Accelerating Drug Discovery with Intelligence and Biological Connections
Dr. Marina Melchiors, Ph.D.
Customer Success Specialist, CAS
12:30 -14:00pm – 23rd
Lunch
14:30 -16:00pm – 23rd
Free time
16:00 – 17:30pm – 23rd
Coffee + Poster Session II
19:00pm – 23rd
SOCIAL EVENT: Pool Party Barbecue
Limited to those who purchased the invitation
9:00 – 10:20am – 24th
Tematic Session III:
Lead-Optimization & DMPK
Chairs: Sabrina B. Ferreira & Rafaela Ferreira
9 – 9:40 am – SPEAKER 17
Optimization of Neurolysin Activators as Potential Therapeutic Options in Ischemic Stroke
Dr. Paul C. Trippier
University of Nebraska
9:40 – 10:20 am – SPEAKER 18
My 4 decades journey in Pharma : riding the wave of change
Dr. Luc Van Hijfte
Novalix, Senior advisor Drug Discovery
10:20 – 10:50am – 24th
CoffeE-break
10:50 – 12:30am – 24th
Tematic Session III:
Lead-Optimization & DMPK
Chairs: Sabrina B. Ferreira & Rafaela Ferreira
10:50 – 11:20 am – SPEAKER 19
In Vitro and In Vivo Development of β-Lactam-Metallo-β-Lactamase Inhibitors: Targeting Carbapenem-Resistant Enterobacterales
Dr. Tricia Naicker
University of KwaZulu-Natal
11:20 – 11:50 am – SPEAKER 20
Probing the Protein Kinases′ Cysteinome by Covalent Fragments
Dr. Matthias Gehringer
University of University of Tübingen
Photo Copyright: Universitätsklinikum
Tübingen / Beate Armbruster”
11:50 – 12:20 am – SPEAKER 21
From Concept to Practice: The Contribution of PBPK Modeling in Early Drug Development
Dr. Andrea Diniz
Universidade Estadual de Maringá
12:30 -14:00pm – 24nd
Lunch
9:00 – 10:20am – 24th
Tematic Session IV:
Frontiers in drug discovery
Chair: Arthur Kummerle & João Paulo S. Fernandes
9 – 9:40 am – SPEAKER 22
Deconvoluting RNA Binding proteins as drug targets, by chromatography-based chemical fragment screening
Dr. Katlin Brauer Massirer
Researcher at the Center for Molecular Biology and Genetics at Unicamp
9:40 – 10:20 am – SPEAKER 23
3′-Deoxy-3′,4′-didehydro-nucleosides and ProTides as Potent Antiviral Agents
Dr. Daniel A. Harki
University of Minnesota
10:20 – 10:50am – 24th
CoffeE-break
10:50 – 12:30am – 24th
Tematic Session IV:
Frontiers in drug discovery
Chair: Arthur Kummerle & João Paulo S. Fernandes
10:50 – 11:20 am – SPEAKER 24
Using DNA-Encoded Libraries for Drug Discovery in Academia
Dr. Damian W. Young
Baylor College of Medicine, USA
11:20 – 11:50 am – SPEAKER 25
Microfluidic “organ-on-a-chip” tissue culture model systems
for drug testing and toxicity studies
Dr. Stefan Wölfl
University of Heidelberg
11:50 – 12:20 am – SPEAKER 26
Pushing Ethical and Scientific Frontiers: Tissue Engineering and Organs-on-a-Chip for Therapy Development
Ana Carolina Migliorini Figueira
Lider Researcher, Advanced Cluster in Tissue ENginerring – NuTET /
Advanced Cluster in Helth Technologies – NATS / Laboratorio Nacional de Biociências -LNBio – CNPEM
12:30 – 14:00pm – Sponsor’s Lecture 2
ACS on Campus
Dr. Matthias Gehringer, Ph.D., Valtair Júnior, M.Sc., and Dr. Marina Melchiors, Ph.D.
14:00 – 15:00pm – 24th
Lecture 3
Chair: Vitor Francisco Ferreira
Discovery and Development of CFTR Modulators for the Treatment of Cystic Fibrosis
Ashvani Singh
Senior Principal Research Scientist, Abbvie, USA
15:00 – 16:00pm – 24th
Lecture 4
Chair: Maria Cristina Nonato
Discovery of NTX-801, a potent Cbl-b inhibitor with antitumor activity in syngeneic models
Dr. Silvana Leit
Executive Director, Nimbus Therapeutics. US
16:00 – 16:30pm – 24th
CoffeE-break
16:30 – 18:30pm – 24th
Coordinated session 1
Chairs: Marcela Moraes & Jean L. dos Santos
16:30 – 18:30pm – 24th
Coordinated session 2
Chairs: Nailton Nascimento Jr & Marjorie Bruder
18:30 – 19:30pm – 24th
Closing Ceremony
Chairs: Dr. Floriano Paes & Dr. Lídia Lima