Carlos Roque Duarte Correia

Full professor at UNICAMP, where he acted as vice-director of the Chemistry Institute (2009-2010), and coordinator of the School of Pharmacy of Unicamp for two periods. Dr. Correia is a Fellow of the Royal Society of Chemistry and among the many awards he received the two most recent are for his innovative work at Unicamp (Inventors Award in 2018 and 2019 – Granted Patent category). Prof. Correia has over 140 publications in international journals, a book on the chemistry of alkaloids, and eight patents (two international).

Synthesis of Natural and Unnatural Marinoquinolines as Anti-plasmodial and Anti-toxoplasm agents

The WHO 2022 Malaria Report, estimated 247 million cases and 619,000 deaths with the majority of infants under-five caused by malaria. Efforts to control the disease have decreased significantly the burden since 2000; however, this progression seems to be stalled during the last four years. 

Based on the potential of macrocycles and on our previous work, we obtained tetra, penta and hexacyclopeptides, containing N-methyl amino acids to evaluate how N-methylation and/or the ring size affect the bioactivity of cyclopeptidic antimalarial compounds.

The syntheses of peptides by SPPS (Solid Phase Peptide Synthesis), the solution or on-resin macrocyclization using two methodologies,the activity and selectivity against the P. falciparum were performed. Several compounds showed subnanomolar or nanomolar EC50 and high selectivity. Furthermore, two cyclopeptides have confirmed in vivo efficacy after oral administration. New investigations allowed us to obtain 4 polymeric nanoparticles containing active compounds that are being tested.