ABSTRACT SUBMISSIONS POSTPONED
TO JULY 15, 2022
Title: Modified Isoflavonoids: Design, Synthesis and Antiproliferative Activity
Abstract: An antiproliferative natural pterocarpan was the starting point to design synthetic pterocarpanquinones. After a SAR study of these compounds in a panel of cancer cells, including some with MDR phenotype, LQB-118 was selected for in vivo experiments and presented anti-cancer (leukemia, prostate) and antileishmanial properties in mice. Additional SAR studies led to LQB-223, a 5-carba-11-aza-pterocarpan. This compound and some structural analogues presented potent antiproliferative effect in leukemia and mama cancer cell lines. New pterocarpans, 5-Carba-pterocarpans and 1-carba-isoflavanones were also synthesized and showed promising antiproliferative activity. The synthesis of these compounds and possible mechanisms of action will be discussed.