Scientific Program – BrazMedChem

Poster presentations at the 10th BrazMedChem will not follow a template. Authors may prepare their posters of their own choice and art, trying to present the results with as little text as possible and more figures and graphs attractive to the reader. The maximum poster size should be 120cm high and 90cm wide. All flash presentations 1 to10 (Sessions 1 to 10) should be also presented as posters.

CONFIRA O RESULTADO DASOLIMPÍADAS DE REDAÇÃO BRAZMEDCHEM

BrazMedChem 2022 participants are cordially invited to contribute original research papers or reviews to this Special Issue of Pharmaceuticals. Gratuities will be granted for the first 4 accepted works (from participants of the Symposium) and special discounts on the publication fee for the others.

SUBMISSIONS TO PHARMACEUTICALS

Sunday, 25th September 2022

2:00-6:00 p.m.	Conference Registration	9:00-12:00 a.m.	Short course: Drug Design – Jean Leandro dos Santos Inovação em fármacos no ambiente acadêmico com foco na otimização molecular
6:00-6:30 p.m.	Opening Ceremony	12:00-2:00 p.m.	Lunch
6:30-7:30 p.m.	Opening Conference – Dr. Michael J. Sofia *“The Discovery of Antivirals to Cure Chronic Viral Hepatitis”*	2:00-5:00 p.m.	Short course: Drug Design – Jean Leandro dos Santos *Inovação em fármacos no ambiente acadêmico com foco na otimização molecular*
7:30-11:30 p.m.	Welcome Cocktail

Monday, 26th September 2022

Session 1: Natural Products-based Drug Discovery Chair: Alexandre Orsato – Londrina State University, Brazil		Session 2: Computer-aided Drug Design (CADD) Chair: Marcelo Castilho – Federal University of Bahia, Brazil
9:00-9:45 a.m.	Scott Smid (University of Adelaide, Australia) The Phytochemical Diversity of Cannabis: Exploring this ‘Potpourri’ of Potential for Development of Cannabinoid-based medicines	9:00-9:45 a.m.	Stefano Alcaro (Univ. Magna Græcia of Catanzaro, Italy) *Can in silico* Medicinal Chemistry help the drug discovery of natural compounds?**
9:45-10:15 a.m.	Lucindo Quintans Jr. (Federal Univ. of Sergipe, Brazil) Can we use terpenes in chronic pain models? How cyclodextrins can help it?	9:45-10:30 a.m.	Alan Talevi, PhD – (University of La Plata, Argentina) LIDeB Tools: a Latin American resource of freely available, open-source cheminformatics apps to assist drug discovery projects
10:15-10:45 a.m.	Laurent Picot (University of La Rochelle, France) Plant and algal natural products for tumor and antimicrobial phototherapy: an overview of species, photototoxic molecules and innovations.	10:30-11:00 a.m.	Coffee Break
10:45-11:15 a.m.	Coffee break	11:00-11:45 a.m.	Hugo Verli (Federal Univ. of Rio Grande do Sul, Brazil) How molecular flexibility can enhance drug discovery?
11:15-11:45 a.m.	Raphael Grougnet (University of Paris Descartes, France) Implementation, development, biological evaluations and SAR of a library of polymethoxyflavones	11:45-12:00 a.m.	Flash Presentation: “Maximization of SARS-CoV-2 neutralization by antibodies through Monte Carlo optimization” – Micael D. L. Oliveira (Federal University of Amazonas, Brazil)
11:45-12:00 a.m.	Flash Presentation: “In silico interaction of organic propolis molecules with targets related to oral mucositis” – Mikaela L. de Souza (Federal University of Alfenas, Brazil)	12:00-2:00 p.m.	Lunch
12:00-2:00 p.m.	Lunch
Session 3: MedChem for Drug Addiction Chair: Gisele C. Goulart – Federal University of Minas Gerais, Brazil		Session 4: Pre-clinical Development Chair: Arthur Kümmerle – Federal Rural Univ. of Rio de Janeiro, Brazil
2:00-2:45 p.m.	Fabrício A. Moreira (Federal Univ. of Minas Gerais, Brazil) MedChem for Drug addiction: Targeting the endocannabinoid system	2:00-2:45 p.m.	Marco Aurélio Martins (Fiocruz, Brazil) Gold nanoparticles for the treatment of glucocorticoid insensitive asthma: what we have learned so far?
2:45-3:30 p.m.	Frederico D. Garcia (Federal Univ. of Minas Gerais, Brazil) Preclinical and innovative uses of anticocaine vaccine: the UFMG-V4N2	2:45-3:30 p.m.	Stefan Laufer (University of Tübingen, Gemany) *DISCOVERY AND DEVELOPMENT OF A MKK-4 INHIBITORS TO INCREASE LIVER REGENERATION*
3:30-3:45 p.m.	Flash Presentation: “Pharmacophore mapping combined with dbCICA reveals new insights on ?4?2 and ?7 nicotinic acetylcholine receptors ligand design” – Nailton M. Nascimento-Júnior, Ph.D. (São Paulo State University, Brazil)	3:30-3:45 p.m.	Flash Presentation: “Antitrypanosomal Benzoxazinone Series: Hit-to-Lead Campaign and Multiparametric Optimization” – Maria C. Mollo (State University of Campinas, Brazil)
3:45-4:15 p.m.	Coffee Break	3:45-4:15 p.m.	Coffee Break
Session 5: MedChem for Neglected Diseases Chair: Elizabeth I. Ferreira – University of São Paulo, Brazil		Session 6: MedChem for Neurodegenerative Diseases Chair: Lorane H. Melim – Federal University of Amapá, Brazil
4:15-5:00 p.m.	Rafaela Salgado Ferreira Cruzipains as a target for Chagas disease: inhibitor discovery and characterization of subtypes	4:15-5:00 p.m.	Maria Laura Bolognesi (University of Bologna, Italy) *Multi-target-directed ligands to combat neurodegenerative diseases — Past, present and future*
5:00-5:45 p.m.	Rafael Guido (University of São Paulo, Brazil) *Discovery of Plasmodium falciparum Inhibitors as Lead Candidates for Malaria*	5:00-5:45 p.m.	Andrea Tarozzi (University of Bologna, Italy) Targeting the NLRP3 inflammasome in neurodegenerative diseases
5:45-6:00 p.m.	Flash Presentation: “Cheminformatics-driven identification of new antiplasmodial hits effective against asexual and sexual stages” – Sabrina S. Mendonça (Federal University of Goias, Brazil)	5:45-6:00 p.m.	Flash Presentation: “Triazole grandisin analog prevents memory deficit by antioxidant effects in an Alzheimer’s Disease model” – Erick Y. M. Rodrigues (Federal University of Mato Grosso do Sul, Brazil)
6:00-8:00 p.m.	Poster Session 1	6:00-8:00 p.m.	Poster Session 1

Tuesday, 27th September 2022

BrazMedChem Awards Chair: Gustavo Trossini – President of the Medicinal Chemistry Division – Brazilian Society of Chemistry		BrazMedChem – Scientific Activities for the Local Community Chairs: Aline Guerra – Federal University of Rio de Janeiro, Brazil Claudio Viegas Jr. – Federal University of Alfenas, Brazil Ângelo de Fátima – Federal University of Minas Gerais, Brazil
9:00-9:30 a.m.	Young BrazMedChem Awards	9:00-10:00 a.m.	Awards’ Ceremony of the BrazMedChem Writing Olympics
9:30-10:00 a.m.	Vanguard BrazMedChem Awards	10:00 a.m.- 6 p.m.	Scientific Activities for Local Community
10:00-11:00 a.m.	Senior BrazMedChem Awards	2:00-3:00 p.m.	Theatrical Presentation for Local Community Ciência é Vida (The presentation will be only in Portuguese)
11:00-1:00 p.m.	Coffee Break
1:00-2:00 p.m.	Lunch
2:00-7:00 p.m.	Free Time
7:00-8:00 p.m.	Theatrical Presentation for BrazMedChem Community Ciência é Vida (The presentation will be only in Portuguese)

Wednesday, 28th September 2022

Gender in Medicinal Chemistry: How to make a successfull carreer in Academy and Industry?
9:00-9:20 a.m.	Speaker 1: Elizabeth Igne Ferreira (University of São Paulo) *Medicinal Chemistry: advances and challenges*
9:20-9:40 a.m.	Speaker 2: Maria Emília Sousa (University of Porto, Portugal) Research, Academia, and Outreach Activities in Portugal: a Personal Experience
9:40-10:00 a.m.	Speaker 3: Júlia L. Monteiro (EUROFARMA) Pre-Clinical Development at Eurofarma: how a Brazilian Pharmaceutical Company is investing in Drug Discovery?
10:00-10:30 a.m.	Discussion
10:30 a.m.-12:30 p.m.	Coffee Break/Poster Session 2
12:30-2:00 p.m.	Lunch
Session 7: Multi-target Directed Ligands Chair: Claudio Viegas Jr. – Federal University of Alfenas, Brazil		Session 8: MedChem for Infectious Diseases Chair: Ângelo de Fátima – Federal University of Minas Gerais, Brazil
2:00-2:45 p.m.	Ana Martinez, Biological Research Center (CIB), Spain From the theory to the bench in multitarget drugs for Alzheimer’s disease therapy	2:00-2:45 p.m.	Ian Gilbert – University of Dundee, Scotland) Drug Discovery for Neglected Diseases
2:45-3:30 p.m.	Holger STARK (Heinrich-Heine- Univ. of Duesseldorf) Histamine H₃ Receptor Pharmacophores in Promising Multi-target Directed Ligands	2:45-3:30 p.m.	Maria Emília Sousa (University of Porto, Portugal) Old Sources for New Antimicrobial Drugs: Lessons and Opportunities
3:30-3:45 p.m.	Flash Presentation: “Heterocyclic multitargeting ligands of cholinesterases, histamine, and dopamine receptor subtypes: promising agents for cognitive dysfunctions” – João Paulo S. Fernandes (Federal University of São Paulo, Brazil)	3:30-3:45 p.m.	Flash Presentation: “Computational Approach for the Rational Development of Inhibitors of NS5 methyltransferase Serotype 2-Dengue” – Natalia Díaz Carpintieri (University of the Republic, Uruguay)
3:45-4:15 p.m.	Coffee Break	3:45-4:15 p.m.	Coffee Break
Session 9: MedChem for Orphan Diseases Chair: Flávio Emery – University of São Paulo – Ribeirão Preto, Brazil		Session 10: MedChem for Cancer Chair: Maria Emília Sousa – University of Porto, Portugal
4:15-5:00 p.m.	Jean Leandro dos Santos (State University of São Paulo, Brazil) Fetal hemoglobin inducers for Sickle Cell Disease	4:15-5:00 p.m.	Paulo R. Costa (Federal Univ. of Rio de Janeiro, Brazil) Modified Isoflavonoids: Design, Synthesis and Antiproliferative Activity
5:00-5:45 p.m.	Angela Russel (University of Oxford, UK) Development of next generation utrophin modulators for Duchenne muscular dystrophy: learning from clinical setbacks	5:00-5:45 p.m.	Antonello Mai (University of Rome, Italy) Together is Better: Epigenetic Polypharmacology
5:45-6:00 p.m.	Flash Presentation: “In Silico Study of the Free Energy of Binding of Kallikrein Inhibitors” – Wemenes J. L. Silva (Federal University of ABC, Brazil)	5:45-6:00 p.m.	Flash Presentation: “Development of Dihydrodiazepinones as Inhibitors of the human Vaccinia-related Kinase 2 (VRK2)” – Marcela Campelo R. Silva (State University of Campinas, Brazil)
6:00-7:00 p.m.	Poster Awards and BrazMedChem Awards (Previous Organizers)
7:00-8:00 p.m.	Closing Ceremony