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LIDeB Tools: a Latin American resource of freely available, open-source cheminformatics apps to assist drug discovery projects Abstract: Cheminformatics is the chemical discipline dealing with the storage, retrieval, analysis, and manipulation of the increasing volume of available chemical data; today,…

Prof. Alan Talevi was born in Buenos Aires, 1980. He obtained his Pharmacy degree in 2004 and completed his Ph.D. studies in 2007, both at the University of La Plata (UNLP, Argentina). Among other recognitions, he was granted the award…

From the theory to the bench in multitarget drugs for Alzheimer's disease therapy Abstract: Multitarget approach strategy is a new emergent paradigm in drug design that is gaining stage in the pharmacotherapy of complex diseases. Among them, neurodegenerative pathologies, characterized…

Raphael Grougnet obtained a degree in Pharmacy (2000) and M.Sc. degree in Medicinal and Biological Sciences at the Paris Descartes University, France (2000), where he performed a Ph.D. in Pharmacy (2006) under the supervision of Prof. F. Tillequin and S.…

Ana Martinez is a researcher and professor at the Center for Biological Research (CIB) of the Spanish National Research Council (CSIC) in Barcelona, Spain. Since more than 30 years ago, her interest is focused on neurodegenerative disorders, leading numerous research…

Pre-Clinical Development at Eurofarma: how a Brazilian Pharmaceutical Company is investing in Drug Discovery? Abstract: The Drug Discovery team is part of Eurofarma’s Innovation Unit that, since 2015, has been working towards expanding the company’s scope of operations at national…

Can in silico Medicinal Chemistry help the drug discovery of natural compounds? Abstract: In silico methods are innovative tools available in several scientific fields. In Medicinal Chemistry they are also widely diffused and, if combined with advanced techniques in structural…

Targeting the NLRP3 inflammasome in neurodegenerative diseases Abstract: Neurodegenerative diseases are characterized by progressive neuronal cell death in different regions of the human brain. Recent studies show that neuroinflammation mediated by innate immunity can actively contribute to the onset and…

Can we use terpenes in chronic pain models? How cyclodextrins can help it? Abstract: Brazilian biodiversity is estimated to represent about 20% of all biodiversity in the world, so its natural wealth is appreciable for several reasons: the discovery of…

Drug Discovery for Neglected Diseases Abstract: The Drug Discovery Unit (DDU) was set up at the University of Dundee in 2006. It is a fully integrated drug discovery unit, combining hit discovery, medicinal and computational chemistry, drug metabolism and pharmacokinetics.…