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Rafaela Salgado Ferreira, PhD

Cruzipains as a target for Chagas disease: inhibitor discovery and characterization of subtypes Abstract: Due to the low efficacy and serious side effects of the currently available pharmacotherapy for Chagas disease, there is a need to develop effective and selective…

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Fabrício A. Moreira, PhD

Title: MedChem for Drug addiction: Targeting the endocannabinoid system Abstract: The endocannabinoid system acts as neurotransmission mechanism modulating various brain functions, such as reward and drug use. This system, named after the herb Cannabis sativa and its chemical constituents (delta-9-tetrahydrocannabinol and others),…

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Babu L. Tekwani, Ph.D.

Title: Tricyclic endoperoxide dimers as promising leads for development of new drugs for drug-resistant Leishmaniasis*   Abstract: Visceral leishmaniasis (VL) caused by protozoan parasite Leishmania donovani, is a major global health challenge. This neglected disease is fatal if left untreated.…

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Paulo R. R. Costa, Ph.D.

Title: Modified Isoflavonoids: Design, Synthesis and Antiproliferative Activity  Abstract: An antiproliferative natural pterocarpan was the starting point to design synthetic pterocarpanquinones. After a SAR study of these compounds in a panel of cancer cells, including some with MDR phenotype, LQB-118…

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Elizabeth I. Ferreira, PhD

Title: Medicinal Chemistry: advances and challenges Abstract: The lecture will present the concepts and principles of Medicinal Chemistry and its contribution to the introduction of drugs in therapeutics. The advances will be shown, with emphasis on the application of Artificial…

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Alan Talevi, PhD

LIDeB Tools: a Latin American resource of freely available, open-source cheminformatics apps to assist drug discovery projects Abstract: Cheminformatics is the chemical discipline dealing with the storage, retrieval, analysis, and manipulation of the increasing volume of available chemical data; today,…

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Ana Martinez, PhD

From the theory to the bench in multitarget drugs for Alzheimer's disease therapy Abstract: Multitarget approach strategy is a new emergent paradigm in drug design that is gaining stage in the pharmacotherapy of complex diseases. Among them, neurodegenerative pathologies, characterized…

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