Pre-Clinical Development at Eurofarma: how a Brazilian Pharmaceutical Company is investing in Drug Discovery? Abstract: The Drug Discovery team is part of Eurofarma’s Innovation Unit that, since 2015, has been working towards expanding the company’s scope of operations at national…
Can in silico Medicinal Chemistry help the drug discovery of natural compounds? Abstract: In silico methods are innovative tools available in several scientific fields. In Medicinal Chemistry they are also widely diffused and, if combined with advanced techniques in structural…
Targeting the NLRP3 inflammasome in neurodegenerative diseases Abstract: Neurodegenerative diseases are characterized by progressive neuronal cell death in different regions of the human brain. Recent studies show that neuroinflammation mediated by innate immunity can actively contribute to the onset and…
Development of next generation utrophin modulators for Duchenne muscular dystrophy: learning from clinical setbacks Abstract: Duchenne muscular dystrophy (DMD) is an X-linked progressive muscle wasting disorder caused by mutations in the dystrophin locus leading to absence of the associated protein,…
Plant and algal natural products for tumor and antimicrobial phototherapy: an overview of species, photototoxic molecules and innovations. Abstract : Bacterial and tumor chemoresistance is a worldwide problem that poses a global threat to human and animal health. Medicine is becoming…
Multi-target-directed ligands to combat neurodegenerative diseases — Past, present and future Abstract: Neurodegenerative diseases are some of the most pressing medical and societal challenges faced by the global population. Although molecular mechanisms are not fully understood, it is widely accepted…
Discovery of Plasmodium falciparum Inhibitors as Lead Candidates for Malaria Abstract: Malaria is one of the most prevalent parasitic infections in the world. In 2020, the disease affected 2441 million people and killed over 600,000 people. Therefore, new drug candidates…
The Phytochemical Diversity of Cannabis: Exploring this ‘Potpourri’ of Potential for Development of Cannabinoid-based medicines Abstract: Cannabis has historically been understudied as a natural source of bioprospecting and drug development; however, with burgeoning access to medicinal cannabis products for therapeutic…
How molecular flexibility can enhance drug discovery? Abstract: The study of molecular flexibility can be traced to the XIX century, as in the study of carbohydrates conformations by Hermann Sachse. However, the word "conformation" appears only in 1929, in a…
DISCOVERY AND DEVELOPMENT OF A MKK-4 INHIBITORS TO INCREASE LIVER REGENERATION Abstract: Currently, the therapeutic options for treatment of liver failure are very limited. In an in vivo RNAi screen, mitogen-activated protein kinase kinase 4 (MKK4) has recently been identified…
