Gold nanoparticles for the treatment of glucocorticoid insensitive asthma: what we have learned so far? Abstract: Asthma is a chronic pulmonary disease that affects millions of people globally and can be fatal. 55% of asthmatics have inadequate control of their…
Minicurso - As aulas serão ministradas em português Inovação em fármacos no ambiente acadêmico com foco na otimização molecular Resumo: A capacidade transformadora da inovação em gerar novos produtos e processos é a forca motriz do desenvolvimento e estímulo à…
Thirty Years Seeking Drugs for Chagas Disease Abstract: Chagas disease, or American trypanosomiasis, an untreating parasitic disease that affect near to 6-7 million people worldwide. The illness is confined mainly in rural areas of 21 Latin American countries (excluding the…
Histamine H3 Receptor Pharmacophores in Promising Multi-target Directed Ligands Abstract: The classic “magic bullet” of Paul Ehrlich follows the rule: one disease – one reason – one drug. Modern therapeutic approaches have detected a number of different diseases caused by…
Together is Better: Epigenetic Polypharmacology Abstract: Recently, despite the great success achieved by the “magic bullets” in the treatment of different diseases through a marked and specific interaction with the target of interest, the pharmacological research is moving toward the…
Preclinical and innovative uses of anticocaine vaccine: the UFMG-V4N2 Abstract: The most promising strategy for treating cocaine addiction is an anti-cocaine vaccine. The treatment is based on the production of anti-cocaine antibodies, which blocks cocaine passage through the blood-brain barrier. The…
Development of next generation utrophin modulators for Duchenne muscular dystrophy: learning from clinical setbacks Abstract: Duchenne muscular dystrophy (DMD) is an X-linked progressive muscle wasting disorder caused by mutations in the dystrophin locus leading to absence of the associated protein,…
Plant and algal natural products for tumor and antimicrobial phototherapy: an overview of species, photototoxic molecules and innovations. Abstract : Bacterial and tumor chemoresistance is a worldwide problem that poses a global threat to human and animal health. Medicine is becoming…
Multi-target-directed ligands to combat neurodegenerative diseases — Past, present and future Abstract: Neurodegenerative diseases are some of the most pressing medical and societal challenges faced by the global population. Although molecular mechanisms are not fully understood, it is widely accepted…
Discovery of Plasmodium falciparum Inhibitors as Lead Candidates for Malaria Abstract: Malaria is one of the most prevalent parasitic infections in the world. In 2020, the disease affected 2441 million people and killed over 600,000 people. Therefore, new drug candidates…
