The Phytochemical Diversity of Cannabis: Exploring this ‘Potpourri’ of Potential for Development of Cannabinoid-based medicines Abstract: Cannabis has historically been understudied as a natural source of bioprospecting and drug development; however, with burgeoning access to medicinal cannabis products for therapeutic…
How molecular flexibility can enhance drug discovery? Abstract: The study of molecular flexibility can be traced to the XIX century, as in the study of carbohydrates conformations by Hermann Sachse. However, the word "conformation" appears only in 1929, in a…
DISCOVERY AND DEVELOPMENT OF A MKK-4 INHIBITORS TO INCREASE LIVER REGENERATION Abstract: Currently, the therapeutic options for treatment of liver failure are very limited. In an in vivo RNAi screen, mitogen-activated protein kinase kinase 4 (MKK4) has recently been identified…
Diego Muñoz-Torrero, PhD Title: Dual inhibition of soluble epoxide hydrolase and acetylcholinesterase: A new avenue for AD treatment Abstract: The enzyme soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs), arachidonic acid metabolites that reduce inflammation and oxidative stress, thereby terminating…
Title: The Discovery of Antivirals to Cure Chronic Viral Hepatitis Abstract: Chronic viral hepatitis caused by the hepatitis B (HBV) and C (HCV) viruses impacts over 350 million individuals globally and is the major cause of liver cirrhosis, liver cancer…
