Session 1: Natural Products-based Drug Discovery Chair: Alexandre Orsato – Londrina State University, Brazil | Session 2: Computer-aided Drug Design (CADD) Chair: Marcelo Castilho – Federal University of Bahia, Brazil |
| 9:00-9:45 a.m. | Scott Smid (University of Adelaide, Australia)
The Phytochemical Diversity of Cannabis: Exploring this ‘Potpourri’ of Potential for Development of Cannabinoid-based medicines | 9:00-9:45 a.m. | Stefano Alcaro (Univ. Magna Græcia of Catanzaro, Italy)
Can in silico Medicinal Chemistry help the drug discovery of natural compounds? |
| 9:45-10:15 a.m. | Lucindo Quintans Jr. (Federal Univ. of Sergipe, Brazil)
Can we use terpenes in chronic pain models? How cyclodextrins can help it? | 9:45-10:30 a.m. | Alan Talevi, PhD – (University of La Plata, Argentina)
LIDeB Tools: a Latin American resource of freely available, open-source cheminformatics apps to assist drug discovery projects |
| 10:15-10:45 a.m. | Laurent Picot (University of La Rochelle, France)
Plant and algal natural products for tumor and antimicrobial phototherapy: an overview of species, photototoxic molecules and innovations. | 10:30-11:00 a.m. | Coffee Break |
| 10:45-11:15 a.m. | Coffee break | 11:00-11:45 a.m. | Hugo Verli (Federal Univ. of Rio Grande do Sul, Brazil)
How molecular flexibility can enhance drug discovery? |
| 11:15-11:45 a.m. | Raphael Grougnet (University of Paris Descartes, France)
Implementation, development, biological evaluations and SAR of a library of polymethoxyflavones | 11:45-12:00 a.m. | Flash Presentation: “Maximization of SARS-CoV-2 neutralization by antibodies through Monte Carlo optimization” – Micael D. L. Oliveira (Federal University of Amazonas, Brazil) |
| 11:45-12:00 a.m. | Flash Presentation: “In silico interaction of organic propolis molecules with targets related to oral mucositis” – Mikaela L. de Souza (Federal University of Alfenas, Brazil) | 12:00-2:00 p.m. | Lunch |
| 12:00-2:00 p.m. | Lunch | | |
Session 3: MedChem for Drug Addiction Chair: Gisele C. Goulart – Federal University of Minas Gerais, Brazil | Session 4: Pre-clinical Development Chair: Arthur Kümmerle – Federal Rural Univ. of Rio de Janeiro, Brazil |
| 2:00-2:45 p.m. | Fabrício A. Moreira (Federal Univ. of Minas Gerais, Brazil)
MedChem for Drug addiction: Targeting the endocannabinoid system | 2:00-2:45 p.m. | Marco Aurélio Martins (Fiocruz, Brazil)
Gold nanoparticles for the treatment of glucocorticoid insensitive asthma: what we have learned so far? |
| 2:45-3:30 p.m. | Frederico D. Garcia (Federal Univ. of Minas Gerais, Brazil)
Preclinical and innovative uses of anticocaine vaccine: the UFMG-V4N2 | 2:45-3:30 p.m. | Stefan Laufer (University of Tübingen, Gemany)
DISCOVERY AND DEVELOPMENT OF A MKK-4 INHIBITORS TO INCREASE LIVER REGENERATION |
| 3:30-3:45 p.m. | Flash Presentation: “Pharmacophore mapping combined with dbCICA reveals new insights on ?4?2 and ?7 nicotinic acetylcholine receptors ligand design” – Nailton M. Nascimento-Júnior, Ph.D. (São Paulo State University, Brazil) | 3:30-3:45 p.m. | Flash Presentation: “Antitrypanosomal Benzoxazinone Series: Hit-to-Lead Campaign and Multiparametric Optimization” – Maria C. Mollo (State University of Campinas, Brazil) |
| 3:45-4:15 p.m. | Coffee Break | 3:45-4:15 p.m. | Coffee Break |
Session 5: MedChem for Neglected Diseases Chair: Elizabeth I. Ferreira – University of São Paulo, Brazil | Session 6: MedChem for Neurodegenerative Diseases Chair: Lorane H. Melim – Federal University of Amapá, Brazil |
| 4:15-5:00 p.m. | Rafaela Salgado Ferreira
Cruzipains as a target for Chagas disease: inhibitor discovery and characterization of subtypes | 4:15-5:00 p.m. | Maria Laura Bolognesi (University of Bologna, Italy)
Multi-target-directed ligands to combat neurodegenerative diseases — Past, present and future |
| 5:00-5:45 p.m. | Rafael Guido (University of São Paulo, Brazil)
Discovery of Plasmodium falciparum Inhibitors as Lead Candidates for Malaria | 5:00-5:45 p.m. | Andrea Tarozzi (University of Bologna, Italy)
Targeting the NLRP3 inflammasome in neurodegenerative diseases
|
| 5:45-6:00 p.m. | Flash Presentation: “Cheminformatics-driven identification of new antiplasmodial hits effective against asexual and sexual stages” – Sabrina S. Mendonça (Federal University of Goias, Brazil) | 5:45-6:00 p.m. | Flash Presentation: “Triazole grandisin analog prevents memory deficit by antioxidant effects in an Alzheimer’s Disease model” – Erick Y. M. Rodrigues (Federal University of Mato Grosso do Sul, Brazil) |
| 6:00-8:00 p.m. | Poster Session 1 | 6:00-8:00 p.m. | Poster Session 1 |
