Pre-Clinical Development at Eurofarma: how a Brazilian Pharmaceutical Company is investing in Drug Discovery? Abstract: The Drug Discovery team is part of Eurofarma’s Innovation Unit that, since 2015, has been working towards expanding the company’s scope of operations at national…
Can in silico Medicinal Chemistry help the drug discovery of natural compounds? Abstract: In silico methods are innovative tools available in several scientific fields. In Medicinal Chemistry they are also widely diffused and, if combined with advanced techniques in structural…
Targeting the NLRP3 inflammasome in neurodegenerative diseases Abstract: Neurodegenerative diseases are characterized by progressive neuronal cell death in different regions of the human brain. Recent studies show that neuroinflammation mediated by innate immunity can actively contribute to the onset and…
Can we use terpenes in chronic pain models? How cyclodextrins can help it? Abstract: Brazilian biodiversity is estimated to represent about 20% of all biodiversity in the world, so its natural wealth is appreciable for several reasons: the discovery of…
Drug Discovery for Neglected Diseases Abstract: The Drug Discovery Unit (DDU) was set up at the University of Dundee in 2006. It is a fully integrated drug discovery unit, combining hit discovery, medicinal and computational chemistry, drug metabolism and pharmacokinetics.…
Research, Academia, and Outreach Activities in Portugal: a Personal Experience Abstract: Achieve gender equality and empower all women and girls is a Sustainable Development Goal (SDG) included in the 2030 Agenda for Sustainable Development, adopted by all United Nations Member…
Bio-orthogonal Reactions: Potential Tools of Current Medicinal Chemistry Hugo Cerecetto, PhD Summary The developments of the last decade in aqueous chemoselective reactions, bio-orthogonal reactions, for biomolecules modifications have provided tools to decorate them with some structural frameworks derived from probes,…
Antonello Mai graduated in Pharmacy in 1984 at the Faculty of Pharmacy of the University of Rome "La Sapienza" with 110/110 cum laude. In June 1992, he obtained the title of PhD in Pharmaceutical Sciences by discussing a thesis entitled…
Implementation, development, biological evaluations and SAR of a library of polymethoxyflavones Abstract : Mainly encountered within the Asteraceae, Rubiaceae and Rutaceae botanical families, polymethoxyflavones are a class of flavonoids with some strong reported biological activities. We have evaluated cytotoxic/chemosensitizing, anti-nociceptive, anti-parasite…
Old Sources for New Antimicrobial Drugs: Lessons and Opportunities Abstract: The decline of the output of the R&D programs of the pharmaceutical companies may have begun to turn around when compared to earlier years of the 21st century. Although one…
